air pollution linked to fertility treatment failure - air cleaner

(Reuters Health)-
A South Korean study shows that women exposed to high levels of air pollution may be less successful in getting pregnant or continuing to get pregnant than women who breathe cleaner air.
The researchers analyzed the pregnancy rate of 9 years and more than 6,600 IVF cycles at the Seoul fertility clinic and found that women exposed to the highest levels of air pollution had lower pregnancy rates and increased pregnancy loss.
"Although the specific mechanism is not clear, it has been suggested that high environmental air pollution will affect the process of IVF assisted conception (IVF)
This means that the impact of air pollution on couples with infertility may be far-reaching, "lead author Dr. Seung-
Ah Choe of CHA University Medical School and CHA fertility clinic in Seoul.
In Human Reproduction, the researchers noted that past studies linked high concentrations of air pollutants from fossil fuel or wood burning to heart disease, stroke and inflammation, and infertility.
To see if pollution affects the success of fertility treatment, the researchers investigated the records of 4,581 women who had experienced one or more IVF cycles from 2006 to 2014.
They used it. Degree of pollution
Monitoring data from 40 locations around the city estimated that each woman was exposed to carbon dioxide, carbon monoxide, sulfur dioxide, ozone and tiny contaminated particles known as PM 10 per hour during fertility treatment.
Choe said in an email that these are the main components of emissions from vehicles, buildings or industrial sites.
The researchers examined the effects of each pollutant in each of the four stages of the IVF process, starting with stimulating the ovary to retrieve the egg, and then transferring the embryo to the uterus, then there is a hormone test to detect early pregnancy and a post-test to confirm the ongoing pregnancy.
The average age of women is 35 years old, half of which have transferred two or more embryos throughout IVF treatment.
In general, about 51% of people are pregnant.
There are 9 per cycle.
Speed of 4%
When the first hormone test indicates that the pregnancy is very early, but the subsequent test indicates that the pregnancy does not last, it is called biochemical pregnancy loss.
For later confirmed pregnancy, called intrauterine pregnancy
The cycle loss rate is 38%.
The researchers found that contamination exposure in the first and third stages of the IVF process was related to loss of pregnancy.
In the early stages, more and more people were exposed to carbon dioxide and carbon monoxide compared to other women, which was associated with a 7% and 6% reduction in access to intrauterine pregnancy, respectively.
In the third stage of IVF, higher exposure to carbon dioxide, carbon monoxide and PM 10 was also associated with a 7% to 8% reduction in the probability of intrauterine pregnancy.
Carbon dioxide and PM 10 exposure were also associated with 17% and 18%, respectively, with a higher chance of loss of biochemical pregnancy.
"Basically, their analysis shows that the level of outdoor activities is high (of pollution)
After the time of ovarian stimulation and the transfer of embryos back to the mother, it is predicted that pregnancy and maintenance of pregnancy are not possible in vitro fertilization (IVF)
Lindsay Darrow, an environmental epidemiology at the Rawlins School of Public Health at Emory University, said in an email: "Patient," he was not involved in the study.
The team noted that the fact that researchers did not have information about other exposures, such as smoking, limited the results of the study.
This analysis is not a controlled experiment designed to determine whether or how air pollution directly affects fertility.
Although the mechanism behind the loss of pregnancy is unclear, Dr.
Matthew Peterson of the University of Utah did not participate in the study, "those of us who have studied particulate matter and other contaminants feel that there are some negative effects mediated by different pathways (such as)
Endocrine Disrupting activities such as multi-aromatic hydrocarbons, micro-chemical activities, or other epigenetic patterns.
Darrow said: "For those who want to get pregnant through test-tube babies, raising awareness may help, for example, by focusing on local air quality indices and avoiding going out at the highest concentration of pollutants.
"But in the end, there is a limit on how much individuals control their air pollution.
Outdoor air pollution is one of the problems that we can really solve only through collective action, "she said. SOURCE: bit.
On April 5, 2018, ly/2Fkyc1U human reproduction.