a prominent air pollutant, indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor - air purifier for asthma

Multi-ring aromatic hydrocarbons exposed to the environment for a long time (PAHs)
It is related to asthma, but its regulatory mechanism is not yet fully clear.
We are reporting a 1-level rise in urine here.
Hydroxypyrene, a biomarker contact with PAH, was found in the asthma department (
However, it is also considered to be a receptor for many environmental contaminants, including benzene [a]pyrene (BaP).
They can be combined directly with AhR and trigger the transfer of AhR to the nucleus, mediating downstream effects including detoxification and other cell reactions.
Some studies have also revealed the role of AhR signals in cancer-causing.
Cumulative evidence suggests that although the experimental results appear to be partly dependent on the dose used, AhR-
The ligand axis is now considered to play a role in the regulation of innate and adaptive immune responses.
For example, our recent evidence shows the important role of AhR.
The ligand axis is used to control the steady state, maturation, and optimal activation of a variety of regulatory cell types, including macrophages and mast cells.
It is worth noting that the ligand
The AhR axis has been shown to be critical in controlling the growth and function of mast cells in calcium (Ca)-
And ros (ROS)-
Rely on fashion.
Dc cells (DCs)
Is the key antigen.
Indicates the type of presenting cell of T cells-
Inflammation mediatedBone marrow-
SOURCE dc (BM-DCs)
And T helper 17 (Th17)
Cells express high levels of AhR.
A previous study showed that,
Studies have shown that PAH is able to inhibit maturation, swallowing activity, IL-
Secretion, T-
Cell stimulating activity of human single-core cellsderived DC .
In addition, it has been shown that AhR promotes IL-
22 regulate the production of T cells and control their expression.
In addition, AhR is activated by typical ligand, TCDD and [form lindolo]3,2-b]carbazole (FICZ)
, Showing a tolerant phenotype that regulates DCs to show that it may promote fox3 to regulate T cell division.
AhR signal also crossed with NF
Kappa B and estrogen receptor signaling pathways are known to play an important role in regulating the immune system.
A recent study has shown that AhR deficiency in DC leads to disturbance of intestinal epithelial development and intestinal immunity.
However, the causal relationship and detailed mechanisms between individual PAH and allergic asthma need to be clarified.
Due to the alarming incidence of allergic diseases in children in Taiwan, we aim to identify the main components of PCBs in the environment and explore their pathogenic role in the development of allergic asthma.
In this study, we prove [1,2,3-cd]pyrene (IP)
It is the main component of the environment of Kaohsiung city in Taiwan, and IP exposure increases the antigen-
The role of induced lung inflammation and IP in the asthma mouse model is at least partially mediated by its effect on ahr-dc function
Dependent way.